Endocrine Abstracts

Deiodinase enzymes have an important role in thyroid hormone metabolism. Type I 5′-monodeiodinase (D1) converts thyroxine (T4) to triiodothyronine (T3), while type III 5-monodeiodinase (D3) inactivates T3 and produces reverse-T3 (rT3) from T4. In fetal sheep, plasma T3 rises towards term in association with the prepartum cortisol surge. This study investigated the effect of cortisol on tissue de...